FIGURE

Fig. 4

ID

ZDB-FIG-210128-168

Publication

Li et al., 2020 - Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish

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Fig. 4

Figure 4Akr1a1b Knockout Altered Adult Zebrafish Kidneys, but Livers Remained Normal (A) Periodic acid-Schiff (PAS) staining and (B) electron microscopy (EM) showed deposition of diastase-resistant PAS-positive hyaline droplets, putatively lysosomes (red arrows), within the epithelium of proximal tubules in Δ-23 akr1a1b-/- kidneys. Akr1a1b+/+ kidneys only have scattered small droplets. Quantification of 19 akr1a1b-/- EM images revealed 9 images with “+” and 10 images with “++” PAS-positive hyaline droplets. All 20 akr1a1b+/+ EM images were scored as “0.” (C) Adult Δ-23 akr1a1b-/- livers stained by PAS were unaltered. Scale bars: 20 μm in (A and C) and 500 nm (B).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	akr1a1b^uh9/uh9; y1Tg
Observed In:	liver pronephric proximal convoluted tubule lysosome
Stage:	Adult

Phenotype Detail

Acknowledgments

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