FIGURE

Figure 6

ID

ZDB-FIG-201213-6

Publication

Oel et al., 2020 - Nrl Is Dispensable for Specification of Rod Photoreceptors in Adult Zebrafish Despite Its Deeply Conserved Requirement Earlier in Ontogeny

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Figure 6

Rod Outer Segments of nrl^−/− Adult Zebrafish Appear Normal

(A) Rods demonstrate the expected hairpin end of floating disks within the outer segment that are non-contiguous with the outer cell membrane (A′), diagnostic of rod cell identity

(B) In wild-type adult zebrafish, photoreceptor synaptic terminals include rod spherules (teal dotted line) that are morphologically distinguishable from cone pedicles (yellow).

(C) In nrl^−/− adult retina, the cone pedicles appear normal, and rod spherules appear normal but are very sparse; instead, electron-lucent terminals (white arrows) uniquely appear and may represent an Nrl-dependent defect in rod synapse maintenance. Various characters of photoreceptor terminals are quantified in Figure S6. Mt, mitochondria; Ms, melanosomes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nrl^{ua5009/ua5009}
Observed In:	retina retina synaptic ribbon
Stage:	Adult

Phenotype Detail

Acknowledgments

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