FIGURE

Fig. 4

ID

ZDB-FIG-201209-5

Publication

Podobnik et al., 2020 - Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish

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Fig. 4

Mutant phenotypes in <italic>D. rerio</italic>, <italic>D. aesculapii</italic> and their hybrids of genes required for heterotopic interactions.

In D. rerio mutations in, a, Cx39.4 (luchs), b, Cx41.8 (leopard), and c, Igsf11 (seurat) lead to spotted patterns, whereas, d, mutations in Kcnj13 (obelix) result in fewer and wider stripes. In D. aesculapii, e–h, mutations in the orthologous genes lead to the complete loss of any pattern. In D. rerio dominant alleles of Kcnj13, i, cause broader stripes and irregularities when heterozygous. Double mutants, j, Cx39.4 k.o.; Kcnj13 k.o., loose almost all melanophores and pattern. Interspecific hybrids between D. rerio and D. aesculapii, which are both mutant, k, for Cx41.8, or, l, for Kcnj13, show patterns of spots or wider stripes similar to the corresponding D. rerio mutants (b, d; n = 15). All images show representative examples of the corresponding genotypes. Scale bars correspond to 1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gja4^t37ui/t37ui gja5b^t1/t1 igsf11^t35ui/t35ui kcnj13^txg6/+ gja4^t37ui/t37ui; kcnj13^txg6/txg6
Observed In:	melanocyte melanophore stripe pigment cell (sensu Vertebrata)
Stage:	Adult

Phenotype Detail

Acknowledgments

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