FIGURE

Figure 5

ID

ZDB-FIG-201102-23

Publication

Santhanam et al., 2020 - A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors

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Figure 5

Cell death and cell proliferation in the P23H transgenic zebrafish. (A,B) Cell death detection using TUNEL staining shows TUNEL-positive dying cells (red) in the P23H zebrafish retina (4 months old). The yellow arrowhead shows a TUNEL-positive cell in the sub-retinal space. (C,D) Yellow arrowheads show the colocalization of Retp1 (green) with TUNEL labeling in the P23H transgenic fish. (E,F) PCNA immunostaining shows many PCNA-positive proliferating cells (green) in the ONL of the P23H zebrafish, but very few in WT. ONL: outer nuclear layer. (G) Numbers of TUNEL positive cells and (H) PCNA-positive cells per 210 µm image field in 4-month old and 6-month old WT and P23H retina (n = 6 fish per genotype; error bars are ± SD; *** p < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	uth4Tg (AB)
Observed In:	retinal outer nuclear layer apoptotic process retinal outer nuclear layer cell population proliferation retinal rod cell apoptotic process
Stage:	Adult

Phenotype Detail

Acknowledgments

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