FIGURE

Fig. 6

ID

ZDB-FIG-200910-39

Publication

Chetty et al., 2020 - Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish

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Fig. 6

Ets1 activity depends on MAPK signaling and phosphorylation of conserved Thr30 and Ser33 residues. (A–F) Confocal micrographs of 12-somite stage Tg(fli1a:GFP) wild-type, XeX:etv2 and XeX:ets1-injected embryos treated with either DMSO (A–C) or 15 μM MAPK inhibitor SL327 (D–F) from 70% epiboly-12-somite stage. Note the absence of ectopic GFP fluorescence in XeX:ets1 embryos treated with SL327 (F) compared to those treated with DMSO (C). (G–I) Confocal micrographs of 15-somite stage Tg(fli1a:GFP) wild-type embryos, XeX:ets1 and XeX:pMut-ets1 (containing Thr30Ala and Ser33Ala mutations) embryos. Note the reduction of ectopic GFP expression in embryos injected with the XeX:pMut-ets1 construct containing mutated phosphorylation sites (I) compared to XeX:ets1-injected embryos (H). White arrowheads indicate ectopic GFP expression.

Expression Data

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Acknowledgments

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Reprinted from Developmental Biology, 465(1), Chetty, S.C., Sumanas, S., Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish, 11-22, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.