FIGURE

Fig. 2

ID

ZDB-FIG-200709-66

Publication

Nyuzuki et al., 2020 - Degeneration of dopaminergic neurons and impaired intracellular trafficking in Atp13a2 deficient zebrafish

Other Figures

Fig. 2

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Fig. 2

Neuropathology of Atp13a2 deficient zebrafish. (A) Axial sections of the posterior tuberculum containing dopaminergic (DA) neurons of zebrafish brain at 4 and 12 months. Right figures in each section are the enlarged images of the left figures. (B) Axial sections of the locus coeruleus containing norepinephrine (NE) neurons of zebrafish brain at 4 and 12 months. Right figures in each section are enlarged images of the left figures. (C) The number of TH + neurons in the posterior tuberculum and the locus coeruleus. (D) The amount of cathepsin D protein in zebrafish brain. WT indicates wild type and KO indicates Atp13a2 deficient zebrafish. (E) Transmission electron microscopy analysis of the middle diencephalon samples from Atp13a2 deficient zebrafish. Atp13a2 deficiency induces lysosome-like bodies that contain granular deposits (arrowheads) and fingerprint-like structures (arrows). Right figures in each section are the enlarged images of the left figures. Scale bars are indicated in A, B and E. *p < 0.05 and ***p < 0.001.

Expression Data

Antibody:	Ab2-ctsd
Fish:	AB atp13a2^nii1/nii1
Anatomical Term:	brain
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atp13a2^nii1/nii1
Observed In:	brain caudal tuberculum dopaminergic neuron diencephalon lysosome dopaminergic neuron locus coeruleus dopaminergic neuron noradrenergic neuron
Stage:	Adult

Phenotype Detail

Acknowledgments

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