FIGURE

Figure 1.

ID

ZDB-FIG-200622-18

Publication

Müller et al., 2020 - RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels

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Figure 1.

<italic>exosc8</italic> and <italic>exosc9</italic> homozygous mutant zebrafish develop microcephaly.

(A) Gross anatomy of 5-dpf wild-type, exosc8 homozygous mutant and exosc9 homozygous mutant zebrafish embryos; lateral view, anterior to the left. Scale bar: 500 μm. (B) Dorsal view of wild-type, exosc8 homozygous mutant and exosc9 homozygous mutant zebrafish embryos. Scale bar: 500 μm. (C, D, E) Standard length, (D) area of eyes, and (E) area of head in 5-dpf wild-type, exosc8 homozygous mutant and exosc9 homozygous mutant zebrafish embryos. 13 control, 8 exosc8 (c.26_27del), and 5 exosc9 (c.198_208del) homozygous larvae were measured for the quantification. Error bars represent the standard error (±SEM), and statistical analysis was performed using unpaired t tests (exosc8 versus wt and exosc9 versus wt, respectively). NS, not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	exosc8^cu201/cu201 exosc9^cu202/cu202
Observed In:	eye head swim bladder
Stage:	Day 5

Phenotype Detail

Acknowledgments

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