FIGURE

Fig. S2

ID

ZDB-FIG-200514-51

Publication

Weber et al., 2020 - Zebrafish disease model of human RNASET2 deficient cystic leukoencephalopathy displays abnormalities in early microglia

Other Figures

All Figure Page

Back to All Figure Page

Fig. S2

Microglia morphology of RNASET2-deficient embryos and larvae in independent clutches.
Zebrafish of the transgenic reporter strain Tg:(PU1:GFP) were analyzed by in vivo confocal laser scanning microscopy (CLSM). Data shown in Figure 1 were filtered to show the morphology of mutant and WT larvae from 5 independent clutches (session 1-5).
A-J Projections of confocal z-stacks through the brain showing microglia (green, arrows). Box A.-J (right panels) showing ramified and vacuoled microglia at increased size as in the respective images A.-J. (left panels). Mutant and WT larvae from the same session are opposed (Session 1: A. mutant & B. WT; Session 2: C. mutant & D. WT; Session 3: E. mutant & F. WT; Session 4: G. mutant & H. WT; Session 5: I. mutant & J. WT
K: Depiction of the morphological categories (ramified, vacuoled, others) of microglia at 5 dpf from 5 sessions.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biol. Open