FIGURE

Figure 9

ID

ZDB-FIG-200421-40

Publication

Adusumilli et al., 2020 - miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation

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Figure 9

miR-7 regulates Wnt/Shh responsiveness and the balance between DA neurons and glia. The model summarizes the in vivo (zebrafish) and in vitro (human cells) findings from this work on miR-7 function, showing the direct regulation of Wnt signaling (by the Wnt-transducer TCF7L2) and possibly indirect regulation of Shh responsiveness, with consequences on the relative amount of DA neurons and glial cells generated during neural progenitor differentiation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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