FIGURE

Fig. 4

ID

ZDB-FIG-200406-192

Publication

Pei et al., 2020 - A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation

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Fig. 4

<italic>gemin3</italic><sup><italic>hg106</italic></sup> mutations impair regeneration of caudal fins and livers.

a Caudal fin regeneration in the control and gemin3^hg106 mutant embryos at 4 days post amputation. Arrows point to the pigment gap which is often missing in the mutants. Scale bar, 100 µm. b Quantification of the area of regenerated caudal fins in the gemin3^hg106 mutants. c Liver regeneration in the control and gemin3^hg106 mutant embryos at 3 days post ablation. The CFP fluorescence labels the regenerated livers. Scale bar, 100 µm. d Quantification of the area of the regenerated livers. Representative images are shown. Liver tissue is labeled by Tg(fabp10a:CFP-NTR). Graphs show mean ± s.e.m. **P < 0.01; ****P < 0.0001. Data for each analysis were collected from ~40 embryos produced from a pairwise heterozygous incross (for fin regeneration), or a pairwise heterozygous incross in the background of the transgene Tg(fabp10a:CFP-NTR) (for liver regeneration).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ddx20^hg106/hg106 ddx20^hg106/hg106; s931Tg
Conditions:	chemical ablation: liver, chemical treatment by environment: metronidazole amputation: ventral fin fold
Observed In:	caudal fin fin regeneration liver liver regeneration
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Regen Med