FIGURE

Fig. 8

ID

ZDB-FIG-200323-11

Publication

Hernandez et al., 2019 - Tmem2 restricts atrioventricular canal differentiation by regulating degradation of hyaluronic acid

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Fig. 8

Hyaluronidase treatment can rescue the bmp4 expression pattern in Ztmem2 mutants. Expression of bmp4 in wt (A, C) and Ztmem2 mutant (B, D) embryos at 48 hpf, as in Figure 2. Pericardial injection of PBS did not alter the bmp4 expression pattern in wt (A) or Ztmem2 mutant (B) embryos (compare to Figure 2A,B). In contrast, pericardial injection of hyaluronidase restored the concentrated expression of bmp4 at the AVC in the majority of the injected Ztmem2 mutants (D, arrowheads; Table 3), but did not affect the bmp4 expression pattern in the majority of the injected wt sibling embryos (C, arrowheads; Table 3)

Expression Data

Gene:	GFP
Fish:	ia4Tg cemip2^sk38/sk38; ia4Tg
Anatomical Terms:	atrioventricular canal myocardium heart
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cemip2^sk38/sk38; ia4Tg
Observed In:	atrioventricular canal myocardium heart
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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