FIGURE

Fig 4

ID

ZDB-FIG-200316-23

Publication

Weuring et al., 2020 - NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome

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Fig 4

Characterization of novel compounds and their effect on Scn1Lab knockout burst movements by 60 minute (light green) or 18 hours (dark green) exposure A) 10μM Veratridine B) 5uM AA43279 C) MV1312 show blocking selectivity for Na_V1.6 over the other human ion channel subtypes but not Na_V1.8. D) 5μM MV1312 E) MV1369 shows blocking selectivity for Na_V1.6 over Na_V1.2, Na_V1.5 and Na_V1.7. F) 50μM MV1369. Dashed lines indicate a novel experimental plate with a seperate experimental group. Error bars = S.D., (-/-) = Scn1Lab knockout, locomotor assays n = 12 per group, selectivity assays n = 3 per group, * <0.05 **<0.005 ***<0.0005.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT scn1lab^zu1/zu1
Conditions:	chemical treatment by environment: sodium channel modulator chemical treatment by environment: veratridine
Observed In:	swimming
Stage:	Day 5

Phenotype Detail

Acknowledgments

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