Fig. 1
- ID
- ZDB-FIG-200217-1
- Publication
- Singh et al., 2019 - αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish
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Zebrafish ?klotho and fgf23 Mutants (A?F) Body condition of ?klotho and fgf23 mutant males at 5 mpf: (A) Tü wild-type strain, (B) ?klotho (kl?5), and (C) fgf23 (fgf23ins1) mutant in Tü background; (D) AB wild-type strain, (E) ?klotho (kl?5), and (F) fgf23 (fgf23?11) mutant in AB background. (G?J) Survival curves for (G) ?klotho (n = 36 background controls, 32 mutants; p < 0.0001) and (H) fgf23 mutants (n = 14 wild-type siblings, 14 mutants; p < 0.0001) in Tü background and for (I) ?klotho (n = 24 wild-type siblings, 21 mutants; p = 0.0001) and (J) fgf23 mutants (n = 60 background controls, 68 mutants; p < 0.0001) in AB background. Log-rank (Mantel-Cox) test for statistical analysis on survival curves in GraphPad Prism. (K and L) Analysis of speed (cm) in the (K) circular arena and (L) home-tank arena. Age (m; mpf) on x axis; n = number of fish. (M and N) ?klotho mutants and wild-type controls in (M) circular and (N) home-tank arena. (O and P) fgf23 mutants and wild-type controls in (O) circular and (P) home-tank arena. Statistical analysis using unpaired t test in GraphPad Prism. |
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Stage: | Adult |