FIGURE

Fig. 3

ID

ZDB-FIG-200101-47

Publication

Li et al., 2019 - SOX19b regulates the premature neuronal differentiation of neural stem cells through EZH2-mediated histone methylation in neural tube development of zebrafish

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Fig. 3

Effect of Sox19b on NSCs in neural tubes. a H&E histological sections of the brain and spinal cord of zebrafish embryos at 24 hpf showed that the number of cells and cell layers in the neural tube decreased, and the ventricle expanded in the Sox19b MO-injected embryos compared with controls. b BrdU labelling of control MO- and Sox19b MO-injected embryos at 24 hpf. Data represent the mean of at least three independent experiments ± SD. **P < 0.01 versus control. c The expression of PCNA was detected by whole-mount in situ hybridization, and the expression was used to detect proliferating cells in zebrafish embryos of control MO MO- and Sox19b MO-injected embryos. d Immunolabelling of HuC (early neuronal marker) at 24 hpf showed that the expression of HuC was ectopic in Sox19b morphants, and the expression of HuC appeared in some regions that were enriched with NSCs. Data represent the mean of at least three independent experiments ± SD. *P < 0.05 versus control

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO6-sox19b WT + MO7-sox19b
Knockdown Reagents:	MO6-sox19b MO7-sox19b
Observed In:	forebrain ventricle neural crest cell development notochord
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Stem Cell Res. Ther.