FIGURE

Figure 3

ID

ZDB-FIG-191230-911

Publication

Cheng et al., 2019 - Ciglitazone-a human PPARγ agonist-disrupts dorsoventral patterning in zebrafish

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Figure 3

Initiation of ciglitazone exposure at 4 hpf results in dorsoventral patterning defects by 24 hpf.

Initiation of ciglitazone (Cig) exposure at 4 hpf does not result in delayed epiboly by 6 hpf (N = 60 embryos per treatment) (A). Mean (± standard deviation) percent of normal, ventralized, dorsalized, or dead embryos following exposure to increasing concentrations of Cig from 4 to 24 hpf (N = 60 embryos per treatment) (B). Asterisk (*) denotes a significant difference (p < 0.05) in the percent of normal embryos relative to vehicle controls (0.2% DMSO). Representative images of (1) a normal embryo exposed to vehicle (0.2% DMSO) (C); (2) ventralized embryos exposed to 9.375 and 12.5 μM Cig (D and E); and (3) a delayed embryo exposed to 15 µM Cig (F). Arrows point to swollen yolk sac extensions, whereas arrowheads point to underdeveloped heads.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by environment: ciglitazone
Observed In:	embryo development ending in birth or egg hatching extension head whole organism
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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