FIGURE

Fig. 8

ID

ZDB-FIG-191230-814

Publication

Thestrup et al., 2019 - A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation

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Fig. 8

An EphB/EphrinB code and myosin II contractility control HPD tubulogenesis. a Graphic representation of domain-specific phenotypes observed in ephrinb1, ephrinb2a, ephb3b and ephb4a mutants; y-axis indicates overall severity of phenotypes. b Graphic representation of domain-specific expression of EphrinB1, EphrinB2a, EphB3b and EphB4a in HPD endoderm and surrounding mesoderm at 52 hpf. c Working model of HPD de novo lumen formation focused on the CBD domain. Lumen formation occurs by a multi-step cord hollowing mechanism, which starts with scattered junctional aggregates, transitions through apical/luminal pocket formation and their subsequent coalescence and finally resolves into a single lumen. Apical/luminal pocket coalescence is promoted by ductal EphrinB1/EphrinB2a interaction with mesodermal EphB3b at the tissue interface and actomyosin contractility

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.