FIGURE

Figure 7

ID

ZDB-FIG-191230-799

Publication

Castro-Sánchez et al., 2019 - Functional analysis of new human Bardet-Biedl syndrome loci specific variants in the zebrafish model

Other Figures

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Figure 7

Representative images of KVs and comparison of average cilia length corresponding to BBS6 conditions. Projections of confocal z-stacks of Alexa fluor 594 and Dapi stained cilia located in Kupffer’s vesicle (KV) from control (A) and bbs6 MO-injected embryos (B), bbs6 MO-injected embryos plus WT capped- mRNA (C) and bbs6 MO-injected embryos plus BBS6 new changes (G411A) capped-mRNA. (D) Note the reduction of the cilia in bbs6 MO-injected and BBS6 variant capped-mRNA co-injected embryos. (E) Comparison of average cilia length. *p < 0.01, **p < 0.001. Scales bars: 10 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO1-mkks
Knockdown Reagent:	MO1-mkks
Observed In:	Kupffer's vesicle cilium
Stage Range:	5-9 somites to 10-13 somites

Phenotype Detail

Acknowledgments

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