FIGURE

Fig. 5

ID

ZDB-FIG-191230-739

Publication

Hall et al., 2019 - Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A

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Fig. 5

lama2^−/− mutant larvae possess defects in muscle stem and progenitor cell formation that are rescued by Laminin protein injection. a–c The transgenic line TgBAC(pax3a:GFP) marks muscle stem and progenitor cells in zebrafish larvae. lama2^−/− mutants (b) possess reduced numbers of pax3a-GFP-positive cells compared to WT (a), quantitated in c (Results expressed as mean ± SD. For each group, n ≥ 11. Statistics: t-test, two-tailed; ****p < 0.0001). d, e Intramuscular injection of fluorescently labelled Laminin protein (red) into lama2^−/− mutants (e) rescues pax3a-GFP-positive cell numbers, and increases them significantly over WT levels (d), quantitated in f (Results expressed as mean ± SD. For each group, n ≥ 7. Statistics: one-way ANOVA, Tukey’s test; *p < 0.05, **p < 0.01). Scale bars, 20 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lama2^{teg15a/teg15a}; i150Tg
Observed In:	myotome muscle stem cell
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Regen Med