FIGURE

Fig. 7

ID

ZDB-FIG-191122-9

Publication

Sufian et al., 2019 - CB₁ and CB₂ receptors play differential roles in early zebrafish locomotor development

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Fig. 7

Effect of the endocannabinoid receptor antagonists AM251 and AM630 on development and inflation of 5 dpf larval zebrafish swim bladders. (A) AM251 and AM630 treatments at the early stage either from 0 to 24?hpf or 24 to 48?hpf showed fully inflated to partial or non-inflated swim bladder (SB; red arrow) development in zebrafish larvae observed at 5 dpf. Representative images of three different fish, labelled 1, 2 and 3, show fully inflated, partially inflated or non-inflated swim bladders in larvae. (B?G) Rates of swim bladder inflation at 0?24?hpf (B?D: n=73, 59, 57 and 58 for vehicle control, 0.5?�mol l^?1 AM251, 5?�mol l^?1 AM630 and 0.5?�mol l^?1AM251+5?�mol l^?1 AM630 treatments, respectively) and at 24?48?hpf (E?G: n=78, 58, 61 and 60 for vehicle control, 0.5?�mol l^?1 AM251, 5?�mol l^?1 AM630 and 0.5?�mol l^?1 AM251+5?�mol l^?1AM630 treatments, respectively). Data are presented as means�s.e.m. ^aSignificantly different from vehicle control, P<0.05; ^bsignificantly different from 0.5?�mol l^?1 AM251, P<0.05; ^csignificantly different from 5?�mol l^?1 AM630, P<0.05 (one-way ANOVA followed by Tukey?s post hoc multiple comparisons test).

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Biol.