FIGURE

Fig. S1

ID

ZDB-FIG-191111-1

Publication

Kumari et al., 2018 - Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors.

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Fig. S1

The reck gene is expressed in neural crest derived and other tissue types during zebrafish

embryogenesis. (A) reck is expressed in the head and tail region of the embryos at Stage 12 H (12 hours post fertilization). (B) At stage

16H, reck is expressed in the optic vesicle, head mesenchymal cells, and somite mesoderm. (C) At stage 19 H, the reck gene is expressed

in a similar pattern with 16 H, but it is more evident in the ventral somites. (D) The reck expression is most evident in the head vasculature,

eye, and ventral vascular primordia at the 24 H stage. (E) At stage 48 H, the reck gene is mainly expressed in the head vascular vessels,

pharyngeal arches, and fin folds. (F) Higher magnification of the head region at stage 48 H (E). The reck expression is most evident in the

head vasculature and pectoral fin fold. ey, eye; hv, head vesicles; mfd, middle fin fold; op, optic vesicle; ot, otic vesicle; pa, pharyngeal

arches; pfd, pectoral fin fold; s, somite; tb, tail bud; vv, ventral vesicles.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	reck^w12/+ rpl35^hi258Tg/+ tp53^zdf1/+ reck^w12/+; rpl35^hi258Tg/+ reck^w12/+; tp53^zdf1/+
Observed In:	whole organism neoplasm whole organism neurofibrosarcoma whole organism primitive neurectodermal tumor
Stage:	Adult

Phenotype Detail

Acknowledgments

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