FIGURE

Fig. S6

ID

ZDB-FIG-190820-18

Publication

Fontenas et al., 2019 - The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones

Other Figures

All Figure Page

Back to All Figure Page

Fig. S6

Knockdown of adora2ab, but not adora2aa, results in peripheralmOPCs. (A) Mean ± SEM of peripheral OPCs in WT olig2:dsred embryos injected with vehicle, 1 ng/nl adora2aa MO1 or 1 ng/nl adora2ab MO1. n = 42 (WT), n = 11 (phenol red), n = 65 (adora2aa MO1) and n = 42 (adora2ab MO1). ***p<0.0001 adora2ab MO1 compared to uninjected. (B) Mean ± SEM of peripheral OPCs at 3 dpf in olig2:dsred;adora2aa-/- larvae injected with adora2ab MO1. n = 44 (uninjected), n = 30 (phenol red) and n = 84 (adora2ab MO1). ***p<0.0001 compared to uninjected. (C) Brightfield images of 3 dpf WT, adora2aa and adora2ab morphant larvae. (D) Mean ± SEM of peripheral OPCs at 3 dpf in olig2:dsred;adora2aa-/-;adora2ab-/- larvae. p=0.75, n = 2 (adora2aa+/+;adora2ab+/+), n = 11 (adora2aa+/+; adora2ab+/-), n = 6 (adora2aa+/+; adora2ab-/-), n = 8 (adora2aa+/-; adora2ab+/+), n = 20 (adora2aa+/-; adora2ab+/-), n = 4 (adora2aa+/-; adora2ab-/-), n = 3 (adora2aa-/-; adora2ab+/+), n = 6 (adora2aa-/-; adora2ab+/-) and n = 4 (adora2aa-/-; adora2ab-/-). Scale bar, 0.5 mm. (E) Mean ± SEM of peripheral OPCs at 3 dpf in olig2:dsred;adora2ab-/- and adora2ab+/+ larvae injected with 1ng/nl adora2ab MO at the one-cell stage. *p = 0.03, n = 20 (adora2ab+/+); n = 13 (adora2ab-/-).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.