FIGURE

Fig. S2

ID

ZDB-FIG-190819-14

Publication

Bercier et al., 2019 - Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities

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Fig. S2

mok ^m632−/− embryo and larvae NMJ structural integrity. a) Double immunohistochemistry reveals the integrity of the NMJ at 2dpf by coverage and colocalization of presynaptic structures (anti-synaptotagmin2, in green) and postsynaptic Ach receptors (α-bungarotoxin, in red). b) Quantification of the colocalization shows normal NMJ structure of the ventral root at 2dpf by both Pearson’s coefficient and the overlap coefficient. c) NMJ structure is also affected at 6dpf, with d) reduced coverage in pre- and postsynaptic components, as well as reduced colocalization. All data presented as average +/− SD; (b: n embryos = 12, 14; d: n larvae = 11,19) (TIF 32575 kb)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dctn1a^m632/m632
Observed In:	CaP motoneuron microtubule CaP motoneuron neuron projection CaP motoneuron synapse microtubule polymerization
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Neurodegener.