FIGURE

Figure 6 figure supplement 3.

ID

ZDB-FIG-190723-937

Publication

Saunders et al., 2019 - Thyroid hormone regulates distinct paths to maturation in pigment cell lineages

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Figure 6 figure supplement 3.

<italic>scarb1</italic> is specifically involved in xanthophore maturation and is induced by TH.

(A) Scarb1 protein alignment. Zebrafish scarb1 mutants had a 105 bp, in-frame deletion in a conserved region of the protein. (B) scarb1 mutants lacked mature, interstripe xanthophores but had normal stripes and aox5:palmEGFP expression, suggesting that patterning and unpigmented xanthophores were normal. (C) In hypothyroid fish treated with exogenous TH (T4), scarb1 expression was rescued within ~1 d (upper) and carotenoid autofluorescence of xanthophores was recovered within ~2 d (lower).

Expression Data

Gene:	scarb1
Fish:	wprt8Tg (AB)
Conditions:	chemical treatment by environment: metronidazole chemical treatment: 3,3',5,5'-tetraiodothyroacetic acid, chemical treatment by environment: metronidazole
Anatomical Term:	xanthophore
Stage:	Days 21-29

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	scarb1^{vp32rc1/vp32rc1} (AB) wprt8Tg (AB) scarb1^{vp32rc1/vp32rc1}; wprt22Tg (AB)
Conditions:	chemical treatment by environment: metronidazole chemical treatment: 3,3',5,5'-tetraiodothyroacetic acid, chemical treatment by environment: metronidazole
Observed In:	xanthophore
Stage:	Days 21-29

Phenotype Detail

Acknowledgments

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