FIGURE

Fig 3

ID

ZDB-FIG-190723-1520

Publication

Oppel et al., 2019 - Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

Other Figures

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Fig 3

Addition of frameshift-mutations in <italic>atrx</italic> to the <italic>p53/nf1</italic>-deficient background induces specific changes in tumor biology.

(A) The morphologic features of p53/nf1/atrx- and p53/nf1-deficient tumors were indistinguishable by visual inspection. (B) When all tumor types were considered, tumor onset was not significantly altered upon heterozygous loss of atrx; a representative tumor watch experiment using line 1 is shown; the tumor watch has been reproduced in lines 1 and 2 with similar results; ns = not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1; nf1b^p303/p303 tp53^zdf1/zdf1; atrx^zdf37/+; nf1b^p303/p303 tp53^zdf1/zdf1; nf1a^p301/+; nf1b^p303/p303 tp53^zdf1/zdf1; atrx^zdf37/+; nf1a^p301/+; nf1b^p303/p303
Observed In:	whole organism whole organism neoplasm
Stage:	Adult

Phenotype Detail

Acknowledgments

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