FIGURE

Figure 4

ID

ZDB-FIG-190723-1487

Publication

Zhu et al., 2019 - Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish via Toxic Gain of Function

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Figure 4

The ahi1 morpholino-injected embryos exhibited retinal ganglion cell (RGC) axon projection defects at 4 dpf. (A) The normal retinotectal projection pattern of WT or control morpholino (Control MO)-injected embryos and defective retinotectal projections in the ahi1 morpholino (ahi1 MO)-injected embryos. Scale bar: 200 μm. (B) The statistical results of the RGC axon length and abnormal middle crossing of WT (n = 106), Control MO- (n = 112), and ahi1 MO- (n = 266) injected embryos. (C) The statistical results of eye sizes of WT and ahi1 MO-injected embryos. (D) The ratios of embryos with normal retinal axon projection (Normal), abnormal middle crossing (Middle crossing), and reduced axon longation (Reduced elongation) in the WT, control MO-, and ahi1 MO-injected embryos. (E) The two-dimensional scatter diagram for eye size in each group. The X-axis represents the length of OT (μm²), and the Y-axis represents the size of eyes (μm²). Error bars denote SEM. ***p < 0.0001 was determined via Student’s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-ahi1
Knockdown Reagent:	MO1-ahi1
Observed In:	eye retinal ganglion cell axon retinal ganglion cell axon extension retinal ganglion cell axon guidance
Stage:	Day 4

Phenotype Detail

Acknowledgments

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