FIGURE

Fig 2

ID

ZDB-FIG-190723-1295

Publication

Krall et al., 2019 - Use of PTC124 for nonsense suppression therapy targeting BMP4 nonsense variants in vitro and the bmp4st72 allele in zebrafish

Other Figures

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Fig 2

Ventroposterior and tail fin defects in <italic>bmp4</italic><sup><italic>st72/st72</italic></sup> homozygous larvae at 3 days post fertilization.

Representative examples of ventroposterior defects scored in bmp4^st72/st72 homozygous larvae at 3 days post fertilization. The panels (Fig 2A–2D) show the tail fin (scale bars = 100 μm). Fig 2A shows a larva scored as an E phenotype (typical appearance with no defects), Fig 2B and 2C show larvae scored as a D phenotype (mild and moderate tail fin defects) and Fig 2D shows a larva scored as a C phenotype (moderate to severe tail fin defect). The sites of the tail fin defects are marked with arrows, except for Fig 2A, in which the arrows show a wildtype tail fin.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmp4^st72/st72
Observed In:	caudal fin cloaca whole organism postero-ventral region
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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