FIGURE

Fig. 1

ID

ZDB-FIG-190708-39

Publication

Breuer et al., 2019 - QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis

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Fig. 1

Characterization of Qdpra.

(A) WISH of qdpra at 24 hpf (dorsal view, anterior to the left) shows staining in retinal pigment epithelium (red arrow) and neural crest cells/melanophore precursor (black arrow). At 48 hpf qdpra transcripts are found in the retinal pigment epithelium, choroid fissure (red arrow) and neural crest cells (black arrow). At 72 hpf and more pronounced at 120 hpf (lateral views, anterior to the left), staining is present in the liver (blue arrow). (B) Lateral views with anterior to the left and (C) dorsal views with anterior to the top of embryos at stages indicated. Knockdown of qdpra results in reduced pigments in the eye (asterisk) at 26 hpf (B) and overall diminished pigmentation at 72 hpf (C). (D) At 72 hpf melanin content is reduced by 20% (of wildtype) in Qdpra hypomorphic zebrafish. (E) Amino acid analysis shows hyperphenylalaninemia and normal tyrosine upon qdpraknockdown.

Expression Data

Gene:	qdpra
Fish:	AB
Anatomical Terms:	eye liver melanoblast melanocyte optic furrow presumptive retinal pigmented epithelium retinal pigmented epithelium
Stage Range:	Prim-5 to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-qdpra
Knockdown Reagent:	MO1-qdpra
Observed In:	eye whole organism whole organism Melanin whole organism phenylalanine whole organism tyrosine
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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