FIGURE

Fig. 6

ID

ZDB-FIG-190626-53

Publication

Chopra et al., 2019 - Zebrafish duox mutations provide a model for human congenital hypothyroidism

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Fig. 6

Hypothyroidism is evident among duox mutants. At 5 dpf, homozygous mutant larvae lack staining for bound T₄ in the thyroid follicles, based on wholemount fluorescent immunohistochemistry (D,E). This is in sharp contrast to the robust staining observed in WT and heterozygous siblings (A–C). The NADPH oxidase inhibitor DPI successfully phenocopies duoxmutations in WT larvae, resulting in an absence of T₄ detection (F). Scale bar: 50 μm.

Expression Data

Antibody:	Ab2-T4
Fish:	AB duox^{sa9892/sa9892} duox^{sa13017/sa13017} duox^sa9892/+ duox^sa13017/+
Condition:	chemical treatment by environment: dibenziodolium
Anatomical Term:	thyroid follicle
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB duox^{sa9892/sa9892} duox^{sa13017/sa13017}
Condition:	chemical treatment by environment: dibenziodolium
Observed In:	thyroid follicle thyroid follicle thyroxine thyroid gland development
Stage:	Day 5

Phenotype Detail

Acknowledgments

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