FIGURE

Fig. 2

ID

ZDB-FIG-190528-2

Publication

Pinho et al., 2018 - Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Behavioral, functional and biochemical parameters in zebrafish treated with MitoPQ vs. Paraquat. Zebrafish were treated with the indicated concentrations of MitoPQ and paraquat, or solvent (control), from 3 dpf until measurements (at 5 or 6 dpf). (A, B) Sensorimotor reflexes and spontaneous movement at 5 dpf: (Ai) tail and (Aii) head reflexes; (Bi) representative trajectories; (Bii) distance; (Biii) initiations, and (Biv) movement speed; n = 27–78 larvae; *P < 0.05 vs. control. (C) Protein carbonyl groups measured by dot-blot at 5 dpf. n = 3 independent experiments, *P < 0.05 vs. control. (D) Left – energy charge values, calculated with the indicated formula, at 5 dpf (triangles) and 6 dpf (circles); Right – representative HPLC chromatogram with adenine nucleotides; n = 3–4 independent experiments. (E) Heart rate and atrioventricular coordination at 6 dpf; n = 16–19 larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Free radical biology & medicine, 130, Pinho, B.R., Reis, S.D., Hartley, R.C., Murphy, M.P., Oliveira, J.M.A., Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells, 318-327, Copyright (2018) with permission from Elsevier. Full text @ Free Radic. Biol. Med.