FIGURE

Fig. 4

ID

ZDB-FIG-190524-24

Publication

Rasouli et al., 2018 - The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

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Fig. 4

Klf2 functions cell non-autonomously to maintain the integrity of the myocardial wall.

(A) Schematic representation of the experiment shown in (B–E). (B–E) Transplantation of Tg(myl7:MKATE-CAAX); klf2^+/+ donor cells into Tg(myl7:LIFEACT-GFP); klf2^+/? (B and D) or klf2^-/- (C and E) hosts shown at 96 hpf; white arrows point to klf2^-/- extruding cardiomyocytes in klf2^-/- heart, orange arrows point to klf2^+/+ extruding cardiomyocytes in klf2^-/- hearts; maximum intensity projections of confocal z-stacks of hearts in (B) and (C) are shown in (D) and (E), respectively. (F) Schematic representation of the experiment shown in (G-J). (G–J) Transplantation of Tg(myl7:LIFEACT-GFP); klf2^+/? (G and I) or klf2^-/- (H and J) donor cells into Tg(myl7:MKATE-CAAX); klf2^+/+ hosts shown at 96 hpf; maximum intensity projections of confocal z-stacks of hearts in (G) and (H) are shown in (I) and (J), respectively. V: ventricle, At: atrium; scale bars, 50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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