FIGURE

Fig. 5

ID

ZDB-FIG-181207-40

Publication

Jiang et al., 2018 - The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation

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Fig. 5

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Fig. 5

Surface melanotic pigmentation phenotypes.

(A) Patches of pigmentation loss in the skin of mosaic mutant G0 fish. (B) T141_L142delinsMISLISV mutants and +/+ sibling fish. (C) N140fs mutants and +/+ sibling fish. (D) No gross melanotic pigmentation phenotype was observed in N140fs homozygous embryos at 50 hpf. When stripes of melanotic pigmentation were visible in heterozygous or homozygous mutant fish, we did not observe obvious differences in the overall pattern of striping between these and wild type fish (data not shown). To assist comparison of images, those indicated by * were inverted (i.e. they actually show the right side of the fish, not the left side).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	psen2^uaa7/uaa7 psen2^uaa8/uaa8 psen2^uaa7/+ psen2^uaa8/+
Observed In:	melanocyte melanophore stripe melanophore stripe melanocyte retinal pigmented epithelium whole organism
Stage Range:	Long-pec to Adult

Phenotype Detail

Acknowledgments

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