FIGURE

Fig. 1

ID

ZDB-FIG-181022-2

Publication

Lawrence et al., 2018 - The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis.

Other Figures

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Fig. 1

col11a2 zebrafish mutant larvae show progressively altered type II collagen protein localization in jaw cartilage. (a,b) Maximum projection of ventral and lateral confocal image stacks from wt (a) and homozygous mutant (col11a2−/−) (b) larvae immunostained for type II collagen at three time points (3, 5 and 7 dpf). White arrows indicate areas of change in type II collagen distribution in the ECM. Dashed insets show single-stack images of regions with reduced deposition (white asterisks represent areas where type II collagen is maintained in mutant fish and red asterisks show fragments of type II collagen-positive material outside the main cartilage elements). Red arrows show interoperculomandibular (IOM) ligament. Scale bar, 100 µm.

Expression Data

Antibody:	Ab1-col2a
Fish:	WT col11a2^{sa18324/sa18324}
Anatomical Terms:	interopercular-mandibular ligament ventral mandibular arch
Stage Range:	Protruding-mouth to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	col11a2^{sa18324/sa18324}
Observed In:	interopercular-mandibular ligament ventral mandibular arch
Stage Range:	Prim-5 to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Phil. Trans. Roy. Soc. Lond., Series B