FIGURE

Fig. 2

ID

ZDB-FIG-180912-53

Publication

Neelathi et al., 2018 - Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.

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Fig. 2

Cxcl12a promotes expression of snail1b in the leading domain. (A,B) snail1b expression at the leading end of the primordium in the control embryos (A) and loss of snail1b expression following cxcl12a knockdown (B). (C) snail1b expression at both ends (brackets) following cxcr7b knockdown. (D) Broad snail1b expression in heat-shocked HS:cxcl12a transgenic embryos (HS-cxcl12a). (E,F) snail1b expression in non-heat-shocked transgenics (NO HS-cxcl12a) (E) and in heat-shocked non-transgenic siblings (HS-Sib) (F). (G) cxcl12a induction in the embryo following heat shock-induced expression of cxcl12a in HS:cxcl12a transgenic embryos. (H,I) Lack of cxcl12a induction in non-heat-shocked (H) and in heat-shocked non-transgenic siblings (I). n=20 for each of two independent experiments. Dotted lines encircle pLL primordia.

Expression Data

Genes:	cxcl12a snai1b
Fish:	zf106Tg zf106Tg + MO4-cxcl12a zf106Tg + MO6-ackr3b zf106Tg; zf51Tg
Condition:	heat shock
Knockdown Reagents:	MO4-cxcl12a MO6-ackr3b
Anatomical Terms:	horizontal myoseptum post-vent region posterior lateral line primordium anterior region posterior lateral line primordium central region posterior lateral line primordium posterior region trunk
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf106Tg + MO4-cxcl12a zf106Tg + MO6-ackr3b zf106Tg; zf51Tg
Condition:	heat shock
Knockdown Reagents:	MO4-cxcl12a MO6-ackr3b
Observed In:	post-vent region posterior lateral line primordium posterior lateral line primordium anterior region posterior lateral line primordium central region posterior lateral line primordium posterior lateral line development trunk
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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