FIGURE

Fig. 2

ID

ZDB-FIG-180823-27

Publication

Grajevskaja et al., 2018 - Analysis of a conditional gene trap reveals that tbx5a is required for heart regeneration in zebrafish

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Fig. 2

tbx5a^tpl58 mutant phenotypes. A-D. Larvae heterozygous for tbx5a^tpl58 gene trap allele display severe but variable fin defects at 5 days post fertilization. Compared to wild type siblings (a), heterozygous mutants display bilaterally equal fin truncation (b), or unequal fin truncation with left (c) or right (d) pectoral fin more severely affected. E. Gene trap homozygotes display a phenotype similar to the more severe version of heartstrings phenotype described previously (Fig 1D and 1E in Garrity et al., 2002). F-H. All adults heterozygous for the gene trap had hearts with enlarged atria and mis-shapen (blunt) ventricles (n = 13). a, atrium, v, ventricle, ba, bulbus arteriosus.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tbx5a^{tpl58Gt/tpl58Gt} tbx5a^tpl58Gt/+
Observed In:	atrium cardiac ventricle heart heart looping pectoral fin
Stage:	Day 5

Phenotype Detail

Acknowledgments

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