FIGURE

Fig. S1

ID

ZDB-FIG-180809-19

Publication

Fleming et al., 2018 - Rapamycin attenuates pathological hypertrophy caused by an absence of trabecular formation

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Fig. S1

erbb2 mutant exhibits more pronounced HL phenotype overtime.

(A,B,E,F) Mid-chamber confocal sections of erbb2 control and erbb2^-/- hearts at 3 and 7 dpf. (A',B',E',F') Magnified high-resolution images of compact myocardial wall and trabecular regions marked by dotted box in A,B,E,F. Yellow arrows point to length of CM (white line) along compact myocardial wall. White arrows point to trabeculae. (C-C'',D-D'',G-G",H-H") Magnified high-resolution images of compact myocardium, revealing sarcomere structures of two CMs. (I, J) Representative images of whole-mount in situ hybridization of nppa in erbb2 control and erbb2^-/- hearts, respectively. (I', J') Magnified images of heart region marked by dotted box in I and J. (n = 12).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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