FIGURE

Fig. 6

ID

ZDB-FIG-180809-12

Publication

Malhotra et al., 2018 - Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

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Fig. 6

Functional compensation between G-protein-coupled receptors from different groups.

(A) Brightfield images showing 10 hpf embryos overexpressing RNA encoding for LPPs (lpp1-varX1, lpp3-varX1) or control RNA. Wild-type (WT) embryos overexpressing Lpps and embryos lacking Cxcr4b function (cxcr4b-/-) developed normally. Cxcr4b-deficient embryos overexpressing Lpps exhibited a delay in gastrulation and failed to close the yolk plug. (B) Graph showing the percentage of embryos with closed yolk plug between 9.75 and 11 hpf. (C) Brightfield images of embryos at 12 hpf. WT embryos overexpressing Lpps and embryos lacking Cxcr4b function (cxcr4b-/-) developed normally and formed six somites by this stage. Embryos lacking Cxcr4b function (cxcr4b^-/-) that overexpress Lpps developed only five somites that appear abnormal. (D) Graph showing the number of somites at 12 hpf in WT and cxcr4b^-/- embryos expressing control or Lpps encoding RNA. 75 pg of RNA encoding each Lpp was injected. Equimolar amounts of control RNA were used. For raw data see Figure 6—source data 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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