FIGURE

Fig. 2

ID

ZDB-FIG-180706-41

Publication

Liu et al., 2018 - CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors.

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Fig. 2

Morphological characteristics of shank3b^?/? larvae and adult zebrafish. a?b Abnormal morphological changes in shank3b^?/? and shank3b^+/? larvae at ~?1 dpf, including severe developmental delay, eye melanin reduction (blue arrow), and tail bending (red arrow) (+/+, N?=?60; +/?, N?=?50; ?/?, N?=?50). c?d Normal morphology and body length of shank3b^+/+, shank3b^+/?, and shank3b^?/? larvae at 3 dpf (c) and adults (6 mpf, male) (d) (N?=?20 for each genotype). e?f Significantly enlarged brain size (e) but normal brain weight (f) in adult male shank3b^?/? (6 mpf) compared to WT zebrafish (N?=?30 for each genotype). *p?<?0.05

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	shank3b^{fdu201/fdu201} (TU)
Observed In:	brain embryo development eye Melanin post-vent region whole organism
Stage Range:	Prim-5 to Adult

Phenotype Detail

Acknowledgments

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