FIGURE

Fig. 2

ID

ZDB-FIG-180626-8

Publication

Garcia et al., 2018 - AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish

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Fig. 2

ahr2^osu1 mutants are resistant to TCDD-induced developmental toxicity.

(A) Lateral view of representative bright field images of 5 dpf ahr2⁺ and ahr2^osu1 zebrafish developmentally exposed to embryo medium (EM), 0.1% DMSO, or 1 ng/mL TCDD. J = jaw, E = eye, PE = pericardial edema, and YE = yolk sac edema. Black bar in bottom right corner = 100 μm. (B) A 5 dpf zebrafish embryo-larval developmental toxicity assay for ahr2⁺ and ahr2^osu1 mutants developmentally exposed to DMSO or TCDD (n = 32). The wild-type embryos exposed to TCDD exhibited significant malformations for 11 endpoints examined, including yolk sac and pericardial edema, and craniofacial malformations. No significant malformations were observed in the AHR2^-null zebrafish exposed to TCDD. Morphological evaluations were completed in a binary notation (present/absent) and statistically compared using Fisher’s exact test at p < 0.05 for each endpoint.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	SPF 5-D ahr2^osu1/osu1 (SPF 5-D)
Condition:	chemical treatment by environment: 2,3,7,8-tetrachlorodibenzodioxine
Observed In:	fin mandibular arch skeleton pericardium whole organism yolk syncytial layer
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One