Fig. 8
- ID
- ZDB-FIG-180516-18
- Publication
- Ojeda Naharros et al., 2017 - Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors
- Other Figures
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SNAP25 mislocalizes in cc2d2a-/- PRs (A-C?) 4 dpf cryosections of wild-type (wt) (A-A?), cc2d2a-/- (B-B?) and ift88-/- (C-C?) retinae stained for SNAP25 (green in A?-C?) and BODIPY (magenta). In wt PRs (A-A?) SNAP25 localizes along the plasma membrane, between the mitochondrial cluster and the OS (arrowhead) and at the synapse. In cc2d2a-/- (B-B?), SNAP25 synaptic localization is preserved but apical mislocalization to a membrane-rich compartment (BODIPY, arrows) is obvious. (C and C?) Despite absence of OSs in the ift88-/- mutant, SNAP25 localizes correctly at the apical membrane of PRs. Scale bars are 10 ?m in all panels. |
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Stage: | Day 4 |
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Stage: | Day 4 |