FIGURE

Fig. 3

ID

ZDB-FIG-180201-13

Publication

Chen et al., 2017 - Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles

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Fig. 3

Visualization of CaP-lipid NPs after tail vein injection in transgenic zebrafish. Sterile filtered non ASO-loaded CaP-lipid NPs containing LissRdB-DSPE (stock, 1:5 or 1:10 v/v) was injected into the vein of zebrafish expressing a green fluorescent reporter in their vasculature (Tg(fli1a:EGFP)). Schematic illustration of the route of injection (A). Expression of EGFP in transgenic fish highlighting the blood vessels (B). Visualization of CaP-lipid NP in 6-day-old transgenic zebrafish 2 h after injection (C). Zoomed image of the treated zebrafish from area indicated by white box, showing distribution and accumulation of CaP-lipid NP in and around blood vessels (D). Overlay of transgenic EGFP expression and CaP-lipid NP distribution (E).

Expression Data

Gene:	EGFP
Fish:	y1Tg
Anatomical Term:	vasculature
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neurosci.