FIGURE

Fig. S2

ID

ZDB-FIG-180118-35

Publication

Lin et al., 2017 - Klf8 regulates left-right asymmetric patterning through modulation of Kupffer's vesicle morphogenesis and spaw expression

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Fig. S2

Heart looping and downregulated expression of spaw and its downstream genes were not caused by induction of p53 expression in klf8 morphants. Embryos co-injected with p53-MO^sp and klf8-MO1^atg or klf8-MO2^atg displayed no-loop or L-loop heart defects at 72 hpf (A). The majority of embryos co-injected with p53-MO^sp and klf8-MO1^atg or klf8-MO2^atg exhibited decreased or absent expression of spaw (B), lft1 (C), lft2 (D), or pitx2 (E) in the left LPM, diencephalon or heart at the 18–22 s stages. Expression levels of gata5 and oep which are known to be expressed in the LPM at the 22 s stage were unaffected by klf8 knockdown (F-M).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biomed. Sci.