FIGURE

Fig. 5

ID

ZDB-FIG-171101-50

Publication

Cheng et al., 2015 - Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation

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Fig. 5

Disruption of Dtx1 expression by using dtx1 ^ΔIII or dtx1 morpholino reduces neuronal differentiation. a The injection of dtx1 ^ΔIII or dtx1 morpholino caused an identical phenotype, which downregulated neurog1 (a) and HuC/D expression (b) The phenotypes caused by the morpholino injection could be rescued by a concomitant injection of dtx1 ^full cRNA. The embryo stages are shown in the bottom left corner of each panel. c qPCR analysis confirmed the results obtained through in situ hybridization in a d Counting the HuC/D-positive cells confirmed the results obtained in b *, P < 0.05; **, P < 0.01; ***, P < 0.001

Expression Data

Gene:	neurog1
Fish:	TU TU + MO1-dtx1
Knockdown Reagent:	MO1-dtx1
Anatomical Terms:	brain neuroblast forebrain neuroblast hindbrain neuroblast neuroblast spinal cord neuroblast whole organism
Stage Range:	Bud to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO1-dtx1
Knockdown Reagent:	MO1-dtx1
Observed In:	brain neuroblast forebrain neuroblast hindbrain neuroblast neuroblast neuron differentiation spinal cord neuroblast whole organism
Stage Range:	Bud to Prim-5

Phenotype Detail

Acknowledgments

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