FIGURE

Fig. S5

ID

ZDB-FIG-170606-17

Publication

Lewis et al., 2017 - Cos2/Kif7 and OSM-3/Kif17 Regulate Onset of Outer Segment Development in Zebrafish Photoreceptors Through Distinct Mechanisms

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Fig. S5

Disc shedding is unaffected in osm-3/kif17^mw405 and cos2/kif7^mw406 retina. (Top, Left) TEM image of 7dpf wild-type retina. Depicted is an OS that has recently undergone disc shedding with a phagosome at the OS tip. Scale bar is 5 µm. (Top, Right) Inset of the white box of the left image clearly showing the phagosome as a distinct structure from the OS. Scale bar is 500 nm. (Bottom) Quantification of disc shedding in control, osm-3/kif17^mw405, and cos2/kif7^mw406 retina. Phagosomes were counted along an average total length of 235±2 µm of RPE for four biological replicates of each genotype. Neither the number of phagosomes per length of RPE nor the area of individual phagosomes show any significant differences between genotypes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kif7^mw406/mw406 kif17^mw405/mw405
Observed In:	phagocyte photoreceptor outer segment layer
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 425(2), Lewis, T.R., Kundinger, S.R., Pavlovich, A.L., Bostrom, J.R., Link, B.A., Besharse, J.C., Cos2/Kif7 and OSM-3/Kif17 Regulate Onset of Outer Segment Development in Zebrafish Photoreceptors Through Distinct Mechanisms, 176-190, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.