FIGURE

Fig. 6

ID

ZDB-FIG-170519-31

Publication

Benz et al., 2016 - miR-19b Regulates Ventricular Action Potential Duration in Zebrafish

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Fig. 6

Phenotype of reggae mutants is partially rescued by loss of miR-19b.

(a) Quantification of heart rate in control injected, MO19b and co-injection of MO19b and MOkcne4 (n > 50 animals from 3 independent experiments; p < 0.005 using one-way ANOVA and unpaired t-test with Welch’s correction). (b) Schematic illustration of miR-19b function. (c) Heterozygous reggae mutants were rescued by miR-19b knockdown (±sd; n = 73 animals from 3 independent experiments; p < 0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kcnh6a^m230/m230 WT + MO2-dre-mir-19b kcnh6a^m230/+ kcnh6a^m230/+ + MO2-dre-mir-19b kcnh6a^m230/m230 + MO2-dre-mir-19b WT + MO1-kcne4 + MO2-dre-mir-19b
Knockdown Reagents:	MO1-kcne4 MO2-dre-mir-19b
Observed In:	cardiac muscle cell action potential involved in contraction heart contraction
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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