FIGURE

Fig. 5

ID

ZDB-FIG-170425-31

Publication

Siegerist et al., 2017 - Acute podocyte injury is not a stimulus for podocytes to migrate along the glomerular basement membrane in zebrafish larvae

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Injured podocytes show increased endocytosis from subpodocyte space dilatations.

Transmission electron micrographs of 3 hours 5 mM MTZ treated Cherry larvae showed appearance of pseudocysts (arrowheads) and numerous endosomes (arrows) close to the pseudocysts (lumen marked with asterisk). Additionally those larvae showed broad effacement of foot processes. In contrast, control treated larvae (0.1% DMSO) showed normal glomerular morphology with regular foot processes and slit diaphragms in between. Note the electron dense Bowman’s space (BS) in MTZ treated larvae (scale bars represent 1 μm, representative images from n = 3 experiments).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2; mpv17^a9/a9; mi1001Tg
Condition:	chemical treatment by environment: metronidazole
Observed In:	podocyte pronephric capsular space pronephros pronephros endosome
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.