FIGURE

Fig. 5

ID

ZDB-FIG-161220-19

Publication

Shen et al., 2016 - Functional antagonism of alpha-subunits of Kv channel in developing brain ventricular system

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Fig. 5

kcng4b modulates proliferation in neuroepithelium. (A-B?) Confocal projection view of Z-scans of embryos stained for phospho-histone 3 (PH3) and DNA (DAPI) at 24?hpf. Dorsal views, anterior to the left. (C) Proliferative index in control and kcng4b GOF embryos. Proliferative index was calculated by counting the number of PH3-positive cells and DAPI-positive neuroepithelial cells of each single confocal optical section using ImageJ cell count function, and expressed as summation of the total number of PH3-positive cells of whole Z-scans per 1000 neuroepithelial cells. ***P<0.001; unpaired t-test, n=5. (D-I) Confocal projection view of Z-scans of control and kcng4b^?/? embryos stained at 24?hpf (D-E?) and 48?hpf (G-H?). (F,I) Proliferative index in controls and kcng4b mutants at 24 (F) and 48 hpf (I). ***P<0.001; unpaired t-test, n=5. Scale bars: 50?�m.

Expression Data

Antibody:	Ab4-h3
Fish:	WT kcng4b^{sq300Gt/sq300Gt}
Anatomical Term:	neuroepithelial cell
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kcng4b^{sq300Gt/sq300Gt}
Observed In:	neuroepithelial cell neuroepithelial cell cell population proliferation
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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