FIGURE

Fig. 3

ID

ZDB-FIG-161107-13

Publication

Marín-Juez et al., 2016 - Fast revascularization of the injured area is essential to support zebrafish heart regeneration

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Fig. 3

Induction of dn-vegfaa expression blocks revascularization of the damaged area. (A) Tg(hsp70l:dn-vegfaa);Tg(etv2:EGFP) ventricle at 40 hpi (n = 5). (A′) Inset shows high-magnification image of the injured area. (B) Tg(etv2:EGFP) WT ventricle at 40 hpi (n = 5). (C) Tg(etv2:EGFP) WT ventricle at 4 dpi (n = 5). (D) Tg(hsp70l:dn-vegfaa);Tg(etv2:EGFP) heart at 4 dpi (n = 3). White arrowheads point to coronary vessels sprouting into the injured area; yellow arrows point to disconnected endothelial cells; asterisk mark an area of coronary plexus. Dotted lines delineate the injured area. AVC, atrioventricular canal; BA, bulbus arteriosus. (Scale bar: 100 µm.)

Expression Data

Gene:	EGFP
Fish:	ci1Tg bns100Tg; ci1Tg
Conditions:	cold damage: heart cold damage: heart, heat shock
Anatomical Terms:	heart vasculature regenerating tissue regenerating tissue vascular sprouts
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bns100Tg; ci1Tg
Condition:	cold damage: heart
Observed In:	regenerating tissue coronary vasculature development regenerating tissue vascular sprouts
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA