FIGURE

Fig. S6

ID

ZDB-FIG-161003-10

Publication

Matsuda et al., 2016 - Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons

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Fig. S6

Notch signaling changes the numbers of cells expressing ebp41l5

(A-B) p53 knockdown does not change expression of her4, a direct target of Notch signaling at 32 hpf. (C-J) p53 knockdown does not change expression of deltaD in DAPT-treated embryos. Lateral views of the hindbrain (C,D,G,H) and dorsal views of the hindbrain (E,F,I,J) at 32 hpf. After 4 hours of DAPT treatment, deltaD expression in the hindbrain paraboundary domains is downregulated and the expression is limited to the hindbrain rhombic lip, suggested that DAPT effectively inhibits Notch signaling and facilitates differentiation of DeltaD-positive NPCs determined to become neurons in p53 deficient embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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