FIGURE

Fig. 4

ID

ZDB-FIG-160927-50

Publication

Zhao et al., 2016 - Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish

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Fig. 4

Enhanced tumor infiltration of neutrophils by induced Myc expression and suppression of neutrophil infiltration by angiogenesis inhibitors.

TO(Myc) and Tg(mpx:EGFP) double transgenic larvae were generated with EGFP labeled neutrophils. (A-F) Images of the double transgenic larvae in the presence of the following chemicals: nil control (A), Dox (B), SU5416 (C), Dox+SU5416 (D), sunitinib (E) and Dox+sunitinib (F). The larvae were treated from 4 dpf to 7 dpf. In all images, the liver areas are circled by dashlines. The original magnification was 20x. (G) Neutrophil counts in the liver. (H) Neutrophil density in the liver. Neutrophil density was calculated as number of neutrophils per µm². (I) Quantification of 2D liver size. The quantitative data were based on 10 samples per concentration group. Data are represented as mean ± SD. Astrisks indicate significant difference with P-value < 0.05 by unpaired t-test statistical analysis.

Expression Data

Gene:	EGFP
Fish:	gz26Tg; rj30Tg
Conditions:	chemical treatment by environment: doxycycline chemical treatment by environment: doxycycline chemical treatment by environment: doxycycline
Anatomical Term:	neutrophil
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz26Tg; rj30Tg
Conditions:	chemical treatment by environment: doxycycline chemical treatment by environment: doxycycline chemical treatment by environment: doxycycline
Observed In:	liver liver neutrophil
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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