FIGURE

Fig. S6

ID

ZDB-FIG-160913-7

Publication

Veldman et al., 2015 - The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model

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Fig. S6

Ubiquitous HTT-exon1-GFP expression in HTT-exon1 and HTT-ΔN17-exon1 lines. 3D projections of confocal images of brain sections from HTT-exon1 L1 (A-C) and HTT-ΔN17-exon1 L1 (D-F) stained for GFP and HuC. Note the faint nuclear GFP staining in HTT while HTT-ΔN17-exon1 has brighter nuclear GFP. (G) Relative nuclear GFP intensity measurements in HuC⁺ cells comparing HTT-exon1-GFP versus HTT-ΔN17-exon1, n = 10 cells each, **p < 0.01, students t-test. Measurments were made using ImageJ and normalized to average GFP intensity across the entire area. HTT-exon1-GFP was arbitrarily set at 100 %. HTT-ΔN17-exon1 nuclei were approximately 20 % brighter.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Neurodegener.